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Diabetes Care 21 , 21912192 (1998)
PIONEER PLUS was therefore designed to evaluate the efficacy, safety, and tolerability of oral semaglutide at doses of 25 mg and 50 mg once daily, compared with the 14 mg once-daily dose that is already in clinical use. Primary outcome measures included change in A1C from baseline to week 52 and from baseline to week 68
The trial demonstrated that semaglutide 2.4 mg (the Wegovy dose) was effective and well-tolerated regardless of baseline medicine use, including statins
But dig deeper into the individual test scores, and you will find variance that matters, overfilling patterns that raise questions, and a pricing structure that divides the research community right down the middle
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